Bramadi Arya

Lecturer, Dept. of Medical Laboratory Technology, Syedza Saintika University

Bio

I am a lecturer in Medical Laboratory Technology at Syedza Saintika University in Padang, West Sumatra.

West Sumatra is where most of Indonesia’s gambir comes from. Gambir is made from Uncaria gambir, and farmers here have grown it for generations, mostly for export. Its wild relatives grow in the forests around us, and the genus is known for oxindole alkaloids that have shown neuroprotective activity in laboratory studies. I want to find out whether wild Uncaria from our own forests can inhibit BACE1, the enzyme that starts the production of amyloid-β in Alzheimer’s disease. That question takes me from collecting plants in the field to LC-MS and GC-MS profiling, molecular docking, and finally an animal model.

The other half of my work starts with people. Indonesia’s population is ageing, yet dementia is still rarely diagnosed here, and there is little genetic data on Alzheimer’s risk in Indonesian populations. With my students, I genotype APOE and related variants and profile the gut microbiota of older adults, so that risk can be studied in the population it actually affects.

My training is in molecular biology, biotechnology, and bioinformatics, and most of my projects combine bench work with computational analysis.

Research Interests

Neurodegenerative disease: BACE1 inhibition, neuroprotective phytochemical compounds
Molecular genomics: APOE genotyping (rs7412, rs429358) and regulatory variants (rs440446), Klotho missense variants (rs9527025, rs9536314)
Clinical biomarkers: cohort studies in elderly populations
Gut-brain axis: microbiota and neurodegeneration
Computational biology: in silico characterization of disease-associated variants, molecular docking, molecular dynamics, GC-MS/LC-MS-based phytochemical analysis

Latest Publications

2026

Integrative In Silico Characterization of Klotho Missense Variants rs9527025 and rs9536314: Structural Perturbation Prediction, Tissue Expression, and Functional Network Analysis

Arya, B., Maliza, R.

Journal of Biotechnology and Natural Science, 6(1), 45–54

DOI Genomics, Bioinformatics

@article{arya2026integrative,
  title = {{Integrative In Silico Characterization of Klotho Missense Variants rs9527025 and rs9536314: Structural Perturbation Prediction, Tissue Expression, and Functional Network Analysis}},
  author = {Arya, B. and Maliza, R.},
  journal = {Journal of Biotechnology and Natural Science},
  year = {2026},
  volume = {6},
  number = {1},
  pages = {45--54},
  doi = {10.12928/jbns.v6i1.16188}
}

2026

Molecular targeting of Bcl-2 in oral cancer cells by nordentatin: An in silico docking and molecular dynamics study

Afriza, D., Maliza, R., Arisanty, D., Arya, B., Rasyadi, Y., Ichwan, S.J.A.

Journal of Baghdad College of Dentistry, 38(2), 52–63

DOI Bioinformatics, Cancer

@article{afriza2026molecular,
  title = {{Molecular targeting of Bcl-2 in oral cancer cells by nordentatin: An in silico docking and molecular dynamics study}},
  author = {Afriza, D. and Maliza, R. and Arisanty, D. and Arya, B. and Rasyadi, Y. and Ichwan, S.J.A.},
  journal = {Journal of Baghdad College of Dentistry},
  year = {2026},
  volume = {38},
  number = {2},
  pages = {52--63},
  doi = {10.26477/jbcd.v38i2.4218}
}

2026

Detection of S989P and V1016G Knockdown Resistance (kdr) Mutations in the Voltage-Gated Sodium Channel (VGSC) Gene of Aedes aegypti Populations in West Sumatra

Hasmiwati, R.M., Arya, B.

Journal of Hunan University Natural Sciences, 53(7)

Genomics, Vector biology

@article{hasmiwati2026detection,
  title = {{Detection of S989P and V1016G Knockdown Resistance (kdr) Mutations in the Voltage-Gated Sodium Channel (VGSC) Gene of \textit{Aedes aegypti} Populations in West Sumatra}},
  author = {Hasmiwati, R.M. and Arya, B.},
  journal = {Journal of Hunan University Natural Sciences},
  year = {2026},
  volume = {53},
  number = {7}
}

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